منابع مشابه
Disquisitions on Original Antigenic Sin
Experiments in rabbits were designed to test the two unproven assumptions of the hypothesis proposed in the companion paper (1): that Original Antigenic Sin is fundamentally a restricted anamnestic response, and that there exists a trapping mechanism capable of deflecting antigen from one kind of cell and guiding it to another. It is shown that whole-body X-irradiation, sufficient to abolish pr...
متن کاملDisquisitions on Original Antigenic Sin I. Evidence in Man* by S. Fazekas
Given a dose of antigen, an organism may or may not respond by producing specific antibody. The contending theories disagree on almost every detail of the mechanism set in motion; they are one in assuming that whatever is or fails to be produced, is specific. Against the background of this tacit assumption any qualitative failure of the antibody response stands out as a major paradox. Thus it h...
متن کاملOvercoming original (antigenic) sin.
Original antigenic sin describes a phenomenon in which the antibody response elicited in an individual after a secondary viral infection reacts more strongly to the viral variant that originally infected the individual. As T helper cells play critical roles in promoting antibody responses, a similar phenomenon may hold true for T helper cell responses. This concept is particularly relevant to t...
متن کاملOriginal antigenic sin in dengue revisited.
The four dengue virus serotypes (DENV-1 to -4) cause the most important arthropod-borne viral disease of humans, with ∼100 million cases each year and over 3 billion people at risk for infection (1). The immune response to DENV infection is complex, because it can be either protective or pathogenic. The “original antigenic sin” in secondary (2°) DENV infections is defined as the dominance of cr...
متن کاملOriginal Antigenic Sin and Pandemic (H1N1) 2009
To the Editor: While pandemic (H1N1) 2009 was in its earliest stages, age distribution data indicated surprisingly few cases among persons >65 years of age. The initial assumption was that few persons >65 years of age had yet to be exposed. However, as more data became available from Mexico, Australia, and the United States, the age distribution pattern persisted (1). This observation raised th...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1966
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.124.3.331